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Tan Q Xie WP Min R Dai GQ Xu CC Pan HQ Miao CD Yang Z Xu WG Wang H 《European journal of clinical microbiology & infectious diseases》2012,31(6):1233-1242
Multidrug-resistant tuberculosis (MDR-TB) has become a lethal global threat. Insights into the immune regulation of MDR-TB
are urgently needed for the development of new treatments; however, the T cell response to an MDR-TB infection in human remains
unclear. In the present study, the proportion of Th1 and Th2 cell subsets and the level of related T cell subset cytokines
in peripheral blood were investigated. We detected that an MDR-TB infection resulted in suppressed Th1 and Th2 cell activation,
which was more remarkable in patients with MDR-TB than that in drug-sensitive tuberculosis (DS-TB) sufferers when compared
to healthy controls (HCs). In addition, MDR-TB infection down-regulated the expression of IFN-γ, IL-2, and IL-10, and up-regulated
IL-4, IL-6, and TNF-α expression. Our data suggest that the disturbance between protective and pathogenic effects induced
by the immunosuppression of Th1- and Th2-type responses is a substantial characteristic of MDR-TB infections. 相似文献
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浙江省蚊虫及蚊媒传染病综合监测研究 总被引:1,自引:1,他引:0
目的通过整合蚊虫及蚊媒传染病监测方案及实施,分析综合监测的可行性,探索病媒生物及相关疾病综合监测模式。方法选择2个病媒生物监测点进行调查研究,整合蚊虫及蚊媒传染病监测方案,协调机构和人员在市及县两个层面上开展综合监测,成蚊综合监测采用诱蚊灯法,监测时间为6-10月。结果在浙江省疾病预防控制中心(CDC)成立执行办公室,综合协调开展工作,宁波市单独完成蚊类密度、季节消长和蚊媒传染病综合监测,建德市完成蚊类密度、季节消长和蚊媒传染病综合监测的现场调查工作,实验室标本检测由浙江省CDC完成,对机构协调、人员数量要求较高。2009年宁波市报告疟疾48例,发病率为0.73/10万;登革热1例,发病率为0.02/10万;流行性乙型脑炎(乙脑)18例,发病率为0.28/10万,死亡1例,病死率为5.56%。建德市无疟疾、登革热及乙脑病例报告。宁波市共捕获蚊类22108只,密度为9.60只/h;建德市共捕获蚊类945只,密度为4.92只/h。宁波市以三带喙库蚊为主,占90%以上,其次为淡色库蚊,白纹伊蚊仅占0.14%;建德市则以淡色库蚊为主,其次为中华按蚊,未捕到白纹伊蚊。宁波市检测三带喙库蚊1973只,乙脑病毒荧光PCR检测有2组阳性,最小阳性率为0.10%。检测建德市库蚊225只,采用巢式PCR检测黄病毒,结果均为阴性。结论蚊虫及蚊媒传染病综合监测是可行的。建议加强蚊虫及其传播疾病的综合监测、预警、控制对策和措施的研究工作。 相似文献
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